Michael Kassiou

This study uses patient-derived tau aggregates to induce disease-specific tauopathy features in human cells, revealing distinct pathological responses across tau strains.

This paper establishes an inducible CB2 expression system in AtT20 cells to quantify ligand efficacy using the operational model, finding that AK-F-064, CP55940, and 2-AG have higher efficacy than AEA.

This study identifies PRDM9 as a factor promoting survival of drug-tolerant persister cells in glioblastoma through metabolic rewiring and cholesterol biosynthesis.

This study differentiates and characterizes iPSC-derived astrocytes and microglia from PSEN2 (N141I) mutation carriers, showing a primed inflammatory phenotype with altered cytokine secretion and Aβ42 handling.

This paper develops a 3D bioprinting platform using iPSC-derived CNS cells to create scalable, biomimetic cultures that support astrocyte growth, vasculogenesis, and enhanced neural differentiation.

The paper identifies differences in mitochondrial protein interaction profiles between wild-type and A147T polymorphism variants of TSPO in human glial cells.