Reverse engineering of the pattern recognition receptor FLS2 reveals key design principles of broader recognition spectra against evading flg22 epitopes
S. H. Zhang, Songyuan Liu, Hung-Fei Lai, Kyle W. Bender, Gijeong Kim, Amedeo Caflisch, Cyril Zipfel
Minimal residue sets were mapped that let blind grape and soybean FLS2 receptors recognize evading flg22 peptides, giving two design principles and an engineered GmFLS2 variant with stronger flg22Rso responses.
Nature Plants · Jul 28, 2025Peer-reviewedPlant Biology✦ In-depth digest