Pharmacological inhibition of all known major inward cationic currents does not block the induction of spreading depolarizations
Preston C. Withers, Allen Jones, Kojo Bawuah Afran-Okese, Bailey J. Calder, Hunter J. Morrill, T. Luke Shafer, Dallin S. Nevers, Jacob H Norby, Rebeca Acosta, Benjamin T. Bikman, Arminda Suli, R. Ryley Parrish
The paper investigates whether blocking major inward cationic currents can prevent spreading depolarizations in zebrafish and mice, finding that these currents are not sufficient to block SD induction.
Frontiers in Cellular Neuroscience · Oct 8, 2025Peer-reviewedNeuroscience