CRISPR-Induced NUT Suppression Promotes Differentiation and Enhances Trop2-Targeted Immunocytokine Response in NUT Carcinoma
Juyoung Choi, Daesik Kim, Joo Youn Oh, Hee Geon Park, Hwa Lin Yi, Yurimi Lee, Hoyeon Jeong, Jiyoung Song, Minjung Sung, Eun Sol Chang, Kyungsoo Jung, Saehyung Lee, Young Kee Shin, Se‐Hoon Lee, Christopher Alexander French, , Yoon‐La Choi
This study shows that CRISPR suppression of NUTM1 promotes differentiation and increases TROP2 in NUT carcinoma cells, enhancing immunocytokine response and improving clinical outcomes.
bioRxiv · Oct 28, 2025 · PreprintCancer Biology