Se‐Hoon Lee

CRISPR-Induced NUT Suppression Promotes Differentiation and Enhances Trop2-Targeted Immunocytokine Response in NUT Carcinoma

This study shows that CRISPR suppression of NUTM1 promotes differentiation and increases TROP2 in NUT carcinoma cells, enhancing immunocytokine response and improving clinical outcomes.

Increased inflammatory signature in myeloid cells of non-small cell lung cancer patients with high clonal hematopoiesis burden

The paper examines the relationship between clonal hematopoiesis burden and immune response in NSCLC patients, finding higher CHIP prevalence in cancer patients and inflammatory pathway enrichment in myeloid cells with severe CHIP.

Unveiling the influence of tumor and immune signatures on immune checkpoint therapy in advanced lung cancer

This study links tumor and immune cell profiles in NSCLC patients to their response to immune checkpoint inhibitors, finding higher CD4+ regulatory T cells and NF-kB/STAT3 activity in non-responders.

Systemic CD8+ T cell effector signature predicts prognosis of lung cancer immunotherapy

The paper identifies a CD8+ T cell effector signature linked to lung cancer immunotherapy prognosis using single-cell RNA sequencing and eQTL analysis.

Systematic analysis of disease-linked rare germline variants reveals new classes of cancer predisposing genes

The paper identifies new cancer predisposing genes by analyzing rare germline variants in Mendelian disease genes across cancer cohorts.

JuLI: accurate detection of DNA fusions in clinical sequencing for precision oncology

JuLI improves DNA fusion detection in clinical sequencing by reducing false positives and increasing sensitivity, outperforming existing methods in high-depth sequencing.