Author

Hyun-Su Lee

University of Pennsylvania

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Bioinformatics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 3 Organism:human· 3 Assay:DNA methylation· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Assay:whole-genome sequencing· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

César de la Fuente‐NúñeziD· 3 shared Marcelo D. T. TorresiD· 3 shared Daniel AndersoniD· 2 shared Fangping WaniD· 2 shared Aaron W. KollaschiD· 1 shared Aaron WeimanniD· 1 shared Abdullah Ali· 1 shared Ahmed M. MoustafaiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersBioengineering

César de la Fuente‐NúñezORCID

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Author profile →

3 papers

Recent·Most cited

Ancient human mitochondrial genomes encode antimicrobial peptides

Marcelo D. T. Torres, Abdullah Ali, Hyun-Su Lee, Fangping Wan, César de la Fuente‐Núñez

The paper identifies antimicrobial peptides encoded in ancient human mitochondrial genomes and validates their activity against bacteria.

bioRxiv · Aug 20, 2026 · PreprintBioengineering

Designing AI-programmable therapeutics with the EDEN family of foundation models

Geraldene Munsamy, Gavin Ayres, Carla Greco, Keith Y K Kam, Gus Minto-Cowcher, John St John, Tanggis Bohnuud, Matthew H. Bakalar, William Chow, Robert J. Pecoraro, Marcelo D. T. Torres, Aaron W. Kollasch, Marcus H. Y. Leung, Hassan Sirelkhatim, Francesco Farina, , Philipp Lorenz

This paper introduces the EDEN family of foundation models for AI-programmable therapeutic design, demonstrating their ability to generate functional gene insertions, antibiotic peptides, and synthetic microbiomes.

bioRxiv · Feb 9, 2026 · PreprintGenomics

AllTheBacteria: a community resource empowers biology and discovers novel peptide antibiotics

Martin Hunt, Marcelo D. T. Torres, Nabil-Fareed Alikhan, Daniel Anderson, Maria Luiza Andreani, Josefin Blom, George Bouras, Fiona S.L. Brinkman, Laura M. Carroll, Matthew A. Croxen, R. Andres Floto, Michael B. Hall, Jane Hawkey, Samuel Horsfield, Baofeng Jia, , Zamin Iqbal

A uniformly processed set of 2,440,377 bacterial and archaeal genomes with search tools and annotations, plus an AI-mined peptide set yielding ATB20, active in a mouse skin infection model.

bioRxiv · Mar 8, 2024 · PreprintBioinformatics✦ In-depth digest