High-content analysis of proteostasis capacity in cellular models of amyotrophic lateral sclerosis (ALS)
I. A. Lambert-Smith, J. J. Yerbury, D. N. Saunders
This paper develops a high-content analysis assay using destabilized firefly luciferase mutants to assess proteostasis disruption in ALS cell models, showing reduced chaperone network activity in SOD1A4V-expressing cells.
bioRxiv · Sep 23, 2021Cell Biology