Isofagomine inhibits multiple TcdB variants and protects mice from Clostridioides difficile induced mortality
A. S. Paparella, I. Brew, H. A. Hong, W. Ferriera, S. Cutting, F. Lamiable-Oulaidi, M. Popadynec, P. C. Tyler, V. L. Schramm
This study shows isofagomine inhibits multiple TcdB variants and protects mice from C. difficile-induced mortality by preserving gut microbiota.
bioRxiv · Sep 19, 2023 · PreprintBiochemistry