Author

P. C. Tyler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1 Organism:plant (other)· 1

Frequent Co-Authors

A. L. Valenciano· 1 shared A. S. Paparella· 1 shared E. F. Merino· 1 shared F. Lamiable-Oulaidi· 1 shared G. J. Butschek· 1 shared H. A. Hong· 1 shared I. Brew· 1 shared K. J. Shaffer· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

A. L. Valenciano

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Isofagomine inhibits multiple TcdB variants and protects mice from Clostridioides difficile induced mortality

A. S. Paparella, I. Brew, H. A. Hong, W. Ferriera, S. Cutting, F. Lamiable-Oulaidi, M. Popadynec, P. C. Tyler, V. L. Schramm

This study shows isofagomine inhibits multiple TcdB variants and protects mice from C. difficile-induced mortality by preserving gut microbiota.

bioRxiv · Sep 19, 2023 · PreprintBiochemistry

Metabolic dependency of chorismate in Plasmodium falciparum

A. L. Valenciano, M. L. Fernandez-Murga, E. F. Merino, N. R. Holderman, G. J. Butschek, K. J. Shaffer, P. C. Tyler, M. B. Cassera

The paper investigates the metabolic dependency of chorismate in Plasmodium falciparum, focusing on ubiquinone biosynthesis and the mechanism of action of MMV688345.

bioRxiv · Jul 13, 2019 · PreprintBiochemistry