The lysine-rich intracellular loop and cell type-specific co-factors are required for IFITM3 antiviral immunity in hematopoietic stem cells
G. Unali, A. M. S. Giordano, I. Cuccovillo, M. Abou Alezz, L. Apolonia, I. Merelli, M. M. Malim, C. Petrillo, A. Kajaste-Rudnitski
This study identifies lysine residues in IFITM3 and cell type-specific co-factors as critical for its antiviral activity in hematopoietic stem cells, revealing a mechanism that can be modulated by Cyclosporine H.
bioRxiv · Apr 6, 2021 · PreprintMicrobiology