The complement pattern recognition molecule CL-11 promotes invasion and injury of respiratory epithelial cells by SARS-CoV-2.
A. Polycarpou, T. Wagner-Gamble, R. Greenlaw, L. A. O'Neill, H. Khan, M. M. Malim, M. Romano, D. Smolarek, K. J. Doores, R. Wallis, L. S. Klavinskis, S. Sacks
This study shows CL-11 promotes SARS-CoV-2 invasion and injury of respiratory epithelial cells, suggesting CL-11 blockade could limit viral pathogenicity.
bioRxiv · Dec 11, 2023 · PreprintImmunology