Circulating neurofilament light chain as a promising biomarker of AAV-induced dorsal root ganglia toxicity in nonclinical toxicology species
K. A. Fader, I. D. Pardo, R. C. Kovi, C. J. Somps, H. H. Wang, V. S. Vaidya, S. K. Ramaiah, M. P. Sirivelu
This study evaluates neurofilament light chain (NF-L) as a biomarker for AAV-induced dorsal root ganglia toxicity in rats and monkeys, showing strong correlation with lesion severity.
bioRxiv · Dec 23, 2021Pharmacology & Toxicology