H. H. Wang

SARS-CoV-2 Omicron BA.2.87.1 Exhibits Higher Susceptibility to Serum Neutralization Than EG.5.1 and JN.1

This study compares the antibody evasion, ACE2 binding, and infectivity of SARS-CoV-2 BA.2.87.1 with EG.5.1 and JN.1, finding BA.2.87.1 has lower immune evasion and reduced infectivity.

Antigenicity and receptor affinity of SARS-CoV-2 BA.2.86 spike

This paper evaluates the antigenicity and receptor affinity of the SARS-CoV-2 BA.2.86 subvariant, finding it not more resistant to human sera than other variants but with specific mAb resistance and high receptor affinity.

SEL1L-HRD1 interaction is prerequisite for the formation of a functional HRD1 ERAD complex

This study shows that the SEL1L-HRD1 interaction is essential for HRD1 ERAD complex function, as its disruption leads to developmental defects and cerebellar ataxia in mice.

Bacterial genome engineering using CRISPR RNA-guided transposases

This paper describes a CRISPR RNA-guided transposase system for efficient bacterial genome engineering, including a computational tool for crRNA design and a protocol for multiplexed DNA insertion.

Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants

This study shows that new SARS-CoV-2 BQ and XBB subvariants have significantly reduced neutralization by vaccines and monoclonal antibodies, suggesting a threat to current immunity.

Spatiotemporal dynamics during niche remodeling by super-colonizing microbiota in the mammalian gut

This study investigates the spatiotemporal dynamics of microbial engraftment in the gut following fecal microbiota transplantation using a murine model.

Antibody Evasion Properties of SARS-CoV-2 Omicron Sublineages

This study characterizes the antigenic properties of SARS-CoV-2 Omicron sublineages BA.1+R346K and BA.2, showing they exhibit significant antibody evasion similar to BA.1.

Circulating neurofilament light chain as a promising biomarker of AAV-induced dorsal root ganglia toxicity in nonclinical toxicology species

This study evaluates neurofilament light chain (NF-L) as a biomarker for AAV-induced dorsal root ganglia toxicity in rats and monkeys, showing strong correlation with lesion severity.

Structural basis for antibody resistance to SARS-CoV-2 omicron variant

The paper reports a cryo-EM structure of the SARS-CoV-2 Omicron spike protein, revealing how mutations alter its conformation and enable antibody resistance.

Striking Antibody Evasion Manifested by the Omicron Variant of SARS-CoV-2

This study shows that the Omicron variant of SARS-CoV-2 is highly resistant to neutralization by convalescent serum and vaccines, and many monoclonal antibodies.

Molecular function limits divergent protein evolution on planetary timescales

The paper examines how molecular function constrains protein divergence over time, finding that sequence and structural similarities stabilize after ~1-2 billion years of evolution.

Quantifying spatiotemporal dynamics and noise in absolute microbiota abundances using replicate sampling

The paper introduces DIVERS, a method to quantify spatiotemporal dynamics and noise in microbiota abundances using replicate sampling and spike-in sequencing, applied to the human gut microbiome.

Real-time capture of horizontal gene transfers from gut microbiota by engineered CRISPR-Cas acquisition

This study uses engineered CRISPR-Cas to capture real-time horizontal gene transfer events from gut microbiota at nucleotide resolution, revealing extensive and rapid transfer of plasmid types, particularly IncX.