CaV1.2 channelopathic mutations evoke diverse pathophysiological mechanisms
M. A. Bamgboye, K. G. Herold, D. C. O. Vieira, M. K. Traficante, P. J. Rogers, M. Ben-Johny, I. E. Dick
This study investigates CaV1.2 channelopathies by analyzing mutations in the S6 region, revealing distinct biophysical effects on activation, VDI, and CDI that contribute to diverse clinical outcomes.
bioRxiv · Jun 13, 2022Biophysics