BiophysicsbioRxiv
CaV1.2 channelopathic mutations evoke diverse pathophysiological mechanisms
M. A. Bamgboye, K. G. Herold, D. C. O. Vieira…·I. E. Dick
This study investigates CaV1.2 channelopathies by analyzing mutations in the S6 region, revealing distinct biophysical effects on activation, VDI, and CDI that contribute to diverse clinical outcomes.
DOI 10.1085/jgp.202213209