High affinity FcγR activating function depends on IRAP+ endosomal-signaling platforms
S. Benadda, M. NUGUE, M. BENS, R. Monteiro, I. Evnouchidou, L. SAVEANU
The paper shows that FcγRI internalizes into IRAP-containing endosomes to sustain signaling, which is essential for antibody-dependent cell-mediated cytotoxicity.
bioRxiv · Jun 24, 2021 · PreprintImmunology