Activation of phospholipase C β by Gβγ and Gαq involves C-terminal rearrangement to release auto-inhibition
I. Fisher, M. L. Jenkins, G. G. Tall, J. E. Burke, A. V. Smrcka
This study investigates how Gβγ and Gαq activate PLCβ by inducing structural changes in its C-terminal domain, leading to increased hydrolase activity.
bioRxiv · Oct 18, 2019Biochemistry