A. V. Smrcka

Internalized beta2-Adrenergic Receptors Inhibit Subcellular Phospholipase C-Dependent Cardiac Hypertrophic Signaling

The paper shows that internalized beta2-Adrenergic Receptors inhibit PLCε signaling at the Golgi, reducing cardiac hypertrophy by blocking PKD and HDAC5 phosphorylation.

Identification of G Protein αi Signaling Partners by Proximity Labeling Reveals a Network of Interactions that Includes PDZ-RhoGEF

The paper identifies G protein αi signaling partners using proximity labeling, revealing a network including PDZ-RhoGEF and functional differences among Gi isoforms.

A Universal Allosteric Mechanism for G Protein Activation

This paper identifies a conserved Gly-Arg-Glu motif that mediates G protein subunit dissociation through an allosteric mechanism, and shows that mutations in this motif cause human diseases.

β-arrestin mediates communication between plasma membrane and intracellular GPCRs to regulate signaling

The paper identifies a third mechanism of intracellular GPCR signaling independent of ligands and endocytosis, mediated by β-arrestin-1.

Activation of phospholipase C β by Gβγ and Gαq involves C-terminal rearrangement to release auto-inhibition

This study investigates how Gβγ and Gαq activate PLCβ by inducing structural changes in its C-terminal domain, leading to increased hydrolase activity.