Author

M. L. Jenkins

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 11

Signature Assays, Organisms & Methods

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Approach:experimental assay· 11 Research Focus:cell signaling & trafficking· 6 Research Focus:protein folding & dynamics· 4 Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Assay:protein structure· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1

Frequent Co-Authors

J. E. Burke· 11 shared M. A. Parson· 6 shared C. K. Yip· 4 shared N. J. Harris· 4 shared H. Ranga-Prasad· 3 shared K. D. Fleming· 3 shared M. K. Rathinaswamy· 3 shared U. Dalwadi· 3 shared

Activity by Year

2019-2024 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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11 shared papersBiochemistry

J. E. Burke

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11 papers

Recent·Most cited

Structure of Calcineurin bound to PI4KA reveals dual interface in both PI4KA and FAM126A

A. L. Shaw, S. Suresh, M. A. Parson, N. J. Harris, M. L. Jenkins, C. K. Yip, J. E. Burke

The paper reports a cryo-EM structure of Calcineurin bound to PI4KA, revealing direct interactions with both PI4KA and FAM126A and their conserved binding sequences.

bioRxiv · Apr 9, 2024Biochemistry

Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain

N. J. Harris, M. L. Jenkins, S.-E. Nam, M. K. Rathinaswamy, M. A. Parson, H. Ranga-Prasad, U. Dalwadi, B. E. Moeller, E. Sheeky, S. D. Hansen, C. K. Yip, J. E. Burke

This study identifies the helical domain of p110γ as an allosteric regulator of PI3Kγ activity, showing distinct roles in p110γ-p84 and p110γ-p101 complexes through phosphorylation or nanobody binding.

bioRxiv · Apr 12, 2023Biochemistry

Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation

Y.-M. Choi, D. Ajjaji, K. D. Fleming, P. P. Borbat, M. L. Jenkins, B. E. Moeller, S. Fernando, S. R. Bhatia, J. H. Freed, J. E. Burke, A. R. Thiam, M. V. Airola

The paper investigates how lipid composition, specifically phosphatidic acid and diacylglycerol, affects PLIN3 recruitment to membranes and LDs, revealing structural changes in the PAT domain.

bioRxiv · Nov 17, 2022Biochemistry

Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs

M. K. Rathinaswamy, M. L. Jenkins, X. Zhang, J. T. Stariha, H. Ranga-Prasad, U. Dalwadi, K. D. Fleming, C. K. Yip, R. L. Williams, J. E. Burke

This study identifies molecular differences between p110γ-p84 and p110γ-p101 complexes that explain their differential activation by GPCRs and Ras.

bioRxiv · Jul 29, 2022Biochemistry

ATP-competitive and allosteric inhibitors induce differential conformational changes at the auto-inhibitory interface of Akt

A. L. Shaw, M. A. Parson, L. Truebestein, M. L. Jenkins, T. A. Leonard, J. E. Burke

This study investigates how ATP-competitive and allosteric inhibitors induce different conformational changes in Akt's auto-inhibitory interface across various phosphorylation states.

bioRxiv · Jul 14, 2022 · PreprintBiochemistry

Oncogenic mutations of PIK3CA lead to increased membrane recruitment driven by reorientation of the ABD, p85 and C-terminus

M. L. Jenkins, H. Ranga-Prasad, M. A. Parson, N. J. Harris, M. K. Rathinaswamy, J. E. Burke

This study identifies unique regulatory mechanisms by which oncogenic PIK3CA mutations enhance PI3K membrane recruitment and activation through structural reorientations.

bioRxiv · Apr 5, 2022 · PreprintBiochemistry

Dynamics of allosteric regulation of the phospholipase C-γ isozymes upon recruitment to membranes

E. Siraliev-Perez, J. Sondek, B. R. S. Temple, Q. Zhang, N. Hajicek, J. E. Burke, J. T. Stariha, R. M. Hoffmann, M. L. Jenkins

This study shows that PLC-gamma1 becomes active upon binding to FGFR1 kinase domain and membrane-bound PIP2, with an oncogenic mutation enhancing this activation.

bioRxiv · Feb 23, 2022Biochemistry

Palmitoylation targets the Calcineurin phosphatase to the Phosphatidylinositol 4-kinase complex at the plasma membrane

I. Ulengin-Talkish, M. A. Parson, M. L. Jenkins, J. Roy, A. Z. Shih, N. St-Denis, G. Gulyas, T. Balla, A.-C. Gingras, P. Varnai, E. Conibear, J. E. Burke, M. S. Cyert

This study identifies palmitoylation as a mechanism that localizes CNA{beta}1 to the plasma membrane and Golgi, enabling its interaction with the PI4KA complex and regulating PI4P production.

bioRxiv · Jul 14, 2021Biochemistry

Biochemical insight into novel Rab-GEF activity of the mammalian TRAPPIII complex

N. J. Harris, M. L. Jenkins, U. Dalwadi, K. D. Fleming, S.-E. Nam, M. A. Parson, C. K. Yip, J. E. Burke

This study investigates the GEF activity of TRAPPIII and TRAPPII complexes toward Rab GTPases using biochemical and structural methods, revealing Rab specificity and membrane interaction mechanisms.

bioRxiv · Jun 1, 2021Biochemistry

Activation of phospholipase C β by Gβγ and Gαq involves C-terminal rearrangement to release auto-inhibition

I. Fisher, M. L. Jenkins, G. G. Tall, J. E. Burke, A. V. Smrcka

This study investigates how Gβγ and Gαq activate PLCβ by inducing structural changes in its C-terminal domain, leading to increased hydrolase activity.

bioRxiv · Oct 18, 2019Biochemistry

Characterisation of the c10orf76-PI4KB complex, and its necessity for Golgi PI4P levels and enterovirus replication

J. A. McPhail, H. Lyoo, J. G. Pemberton, R. M. Hoffmann, W. van Elst, J. R. P. M. Strating, M. L. Jenkins, J. Stariha, F. J. M. van Kuppeveld, T. Balla, J. E. Burke

This study characterizes the c10orf76-PI4KB complex, showing its role in maintaining Golgi PI4P levels and enabling enterovirus replication.

bioRxiv · May 10, 2019Biochemistry