I. G. Bravo

Convergent evolution during host range expansion and virulence increase in a Salmonella bacteriophage

This study evolves a virulent phage to expand its host range and increase virulence, finding convergent mutations in key genes.

Human cellular homeostasis buffers trans-acting translational effects of heterologous gene expression with very different codon usage bias

This study examines how human cellular homeostasis buffers phenotypic effects of heterologous gene expression with extreme codon usage bias by analyzing transcriptomic and proteomic responses.

Variability in codon usage in Coronaviruses is mainly driven by mutational bias and selective constraints on CpG dinucleotide

This study analyzes codon usage bias in 82 Coronaviruses, finding that mutational bias and CpG selection drive variation, with human-infecting coronaviruses showing distinct patterns.

Ecological opportunity, radiation events and genomic innovations shaped the episodic evolutionary history of papillomaviruses

This study reconstructs the evolutionary history of papillomaviruses using phylogenetic dating, revealing time-dependent substitution rates and multiphasic evolutionary periods driven by ecological opportunity.

Loop 1 of APOBEC3C regulates its antiviral activity against HIV-1

This study shows that modifying loop 1 residues in APOBEC3C enhances its antiviral activity against HIV-1 and LINE-1 by improving ssDNA binding and deamination.

Genome plasticity in Papillomaviruses and de novo emergence of E5 oncogenes

This study investigates the evolutionary origin and emergence of E5 oncogenes in papillomaviruses, finding that they likely arose de novo from non-coding regions and contributed to phenotypic diversity.

Origin and evolution of papillomavirus (onco)genes and genomes

This study traces the evolutionary origins and diversification of papillomaviruses, identifying key genomic innovations and their timing in the viral lineage.