The macrophage reprogramming ability of antifolates reveals soluble CD14 as a potential biomarker for methotrexate response in rheumatoid arthritis
S. Fuentelsaz-Romero, C. Barrio Alonso, R. Garcia Campos, M. Torres Torresano, I. Muller, A. Triguero-Martinez, L. Nuno, A. Villalba, R. Garcia-Vicuna, G. Jansen, M. E. Miranda-Carus, I. Gonzalez-Alvaro, A. Puig-Kröger
This study shows that antifolates reprogram macrophages via one-carbon metabolism, revealing soluble CD14 as a biomarker for methotrexate response in rheumatoid arthritis.
bioRxiv · May 11, 2021Immunology