CHK2 inhibition provides a strategy to suppress hematological toxicity from PARP inhibitors.
Z. Xu, C. Vandenberg, E. Lieschke, C. L. Scott, I. J. Majewski
This study identifies CHK2 inhibition as a strategy to reduce hematological toxicity from PARP inhibitors by targeting the p53 pathway in blood cells.
bioRxiv · Jul 28, 2020Cancer Biology