Pyroptosis inhibiting nanobodies block Gasdermin D pore formation
A. Kopp, G. Hagelueken, I. Jamitzky, J. Moecking, L. D. J. Schiffelers, F. I. Schmidt, M. Geyer
This study identifies nanobodies that inhibit GSDMD pore formation without affecting caspase cleavage, providing structural insights and potential drug design frameworks.
bioRxiv · Apr 20, 2023Biochemistry