Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
9 papers
Recent·Most cited
A. Kirchhoff, A.-M. Herzner, C. Urban, A. Piras, R. Düster, J. Wegner, A. Grünewald, T. M. Schlee-Guimaraes, K. Ciupka, P. Leka, R. J. Bootz, A. K. de Regt, B. Kümmerer, M. Honholt Christensen, F. I. Schmidt, , M. Schlee
bioRxiv · Jun 23, 2023 · PreprintImmunology
L. D. J. Schiffelers, S. Normann, S. C. Binder, E. Hagelauer, A. Kopp, A. Alon, M. Geyer, H. L. Ploegh, F. I. Schmidt
This study uses nanobodies to reveal GSDMD pore formation mechanism and shows their therapeutic potential in preventing pyroptosis.
bioRxiv · Apr 20, 2023Immunology
A. Kopp, G. Hagelueken, I. Jamitzky, J. Moecking, L. D. J. Schiffelers, F. I. Schmidt, M. Geyer
This study identifies nanobodies that inhibit GSDMD pore formation without affecting caspase cleavage, providing structural insights and potential drug design frameworks.
bioRxiv · Apr 20, 2023Biochemistry
K. S. ROBINSON, G. A. TOH, M. J. FIRDAUS, K. C. THAM, P. ROZARIO, C. LIM, Y. X. TOH, Z. H. LAU, S. C. BINDER, J. MAYER, C. BONNARD, F. I. SCHMIDT, J. A. COMMON, F. L. ZHONG
This paper shows that Corynebacterium diphtheriae toxin activates NLRP1 inflammasome and pyroptosis in keratinocytes via ribotoxic stress response pathways.
bioRxiv · Jan 16, 2023 · PreprintImmunology
L.-M. Jenster, K.-E. Lange, S. Normann, A. vom Hemdt, J. D. Wuerth, L. D. J. Schiffelers, Y. M. Tesfamariam, F. N. Gohr, L. Klein, I. H. Kaltheuner, D. J. Lapp, J. Mayer, J. Moecking, H. L. Ploegh, E. Latz, , F. I. Schmidt
This study identifies p38 kinases as a central signaling hub for NLRP1 inflammasome activation in response to ribotoxic stress and virus infection.
bioRxiv · Jan 24, 2022Immunology
M. S. J. Mangan, F. Gorki, K. Krause, A. Heinz, T. Ebert, D. Jahn, K. Hiller, V. Hornung, M. Mauer, F. I. Schmidt, R. Gerhard, E. Latz
The paper shows that C. difficile toxin B activates the NLRP3 inflammasome in human macrophages, not the Pyrin inflammasome, and that Pyrin activation can be restored with prolonged priming.
bioRxiv · Jul 7, 2021 · PreprintImmunology
M. Hayn, M. Hirschenberger, L. Koepke, J. H. Straub, R. Nchioua, M. H. Christensen, S. Klute, C. Prelli Bozzo, W. Aftab, F. Zech, C. Conzelmann, J. A. Mueller, S. Srinivasachar Badarinarayan, C. M. Stuerzel, I. Forne, , K. M. J. Sparrer
This study identifies SARS-CoV-2's vulnerability to IFN-γ and -λ due to its inefficient antagonism of type I and II IFN responses, suggesting potential therapeutic strategies.
bioRxiv · Oct 15, 2020Microbiology
J. N. Hansen, F. Kaiser, C. Klausen, B. Stueven, R. Chong, W. Boenigk, D. U. Mick, A. Moeglich, N. Jurisch-Yaksi, F. I. Schmidt, D. Wachten
This study develops a nanobody-based method to target optogenetic tools to the primary cilium, enabling analysis of ciliary signaling and function in vitro and in vivo.
bioRxiv · Feb 4, 2020Cell Biology
F. Martin-Sanchez, V. Compan, A. Tapia-Abellan, A. I. Gomez-Sanchez, M. C. Banos, F. I. Schmidt, P. Pelegrin
The paper shows that ASC oligomers change structure with low intracellular K+ to enhance caspase-1 recruitment, independent of NLRP3, and highlights K+ homeostasis as a key regulator of inflammasome activity.
bioRxiv · Jan 27, 2020Immunology