Author

I. Kursula

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 6 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:plant (other)· 3 Research Focus:protein folding & dynamics· 3 Assay:structural biology· 3 Organism:human· 2 Research Focus:protein structure prediction· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. J. Lopez· 3 shared J. Vahokoski· 3 shared P. B. Rosenthal· 3 shared I. Pires· 2 shared J. E. Molloy· 2 shared L. J. Calder· 2 shared U. Bergmann· 2 shared Y.-F. Hung· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersBiochemistry

A. J. Lopez

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Author profile →

7 papers

Recent·Most cited

Expression and purification of human neutrophil proteinase 3 from insect cells and characterization of ligand binding

F. Khorsand, B. E. Haug, I. Kursula, N. Reuter, R. Brenk

This study expresses and purifies recombinant human neutrophil proteinase 3 (PR3) from insect cells, demonstrating its activity and utility for drug discovery and ligand binding studies.

bioRxiv · Nov 10, 2023Biochemistry

Structure of Toxoplasma gondii glideosome-associated connector suggests a role as an elastic element in actomyosin force generation for gliding motility

Y.-F. Hung, Q. Chen, I. Pires, P. B. Rosenthal, I. Kursula

The paper determines the structure of Toxoplasma gondii GAC and suggests it functions as an elastic element in actomyosin force generation for gliding motility.

bioRxiv · Dec 9, 2022 · PreprintBiochemistry

Structure and function of Plasmodium actin II in the parasite mosquito stages

A. J. Lopez, M. Andreadaki, J. Vahokoski, E. Deligianni, L. J. Calder, S. Camerini, A. Freitag, U. Bergmann, P. B. Rosenthal, I. Siden-Kiamos, I. Kursula

This study characterizes Plasmodium actin II, showing it forms stable filaments, associates with the nucleus in gametocytes and zygotes, and requires methylation of histidine 73 for function.

bioRxiv · Nov 22, 2022 · PreprintBiochemistry

Characterization of Plasmodium falciparum myosin B in complex with the calmodulin-like domain of its light chain MLC-B

I. Pires, Y.-F. Hung, U. Bergmann, J. E. Molloy, I. Kursula

This paper characterizes Plasmodium falciparum myosin B's structure and function, showing its role in red blood cell invasion and identifying regulatory light chains that bind to it.

bioRxiv · May 28, 2022Biochemistry

High-resolution structures of malaria parasite actomyosin and actin filaments

J. Vahokoski, L. J. Calder, A. J. Lopez, J. E. Molloy, P. B. Rosenthal, I. Kursula

This paper presents the first high-resolution structure of the malaria parasite actomyosin motor complex and reveals new atomic details of the ATPase site and conformational changes.

bioRxiv · Jul 2, 2020Biophysics

Biophysical analysis of Plasmodium falciparum Hsp70-Hsp90 organizing protein (PfHop) reveals a monomer that is characterised by folded segments connected by flexible linkers

A. Shonhai, S. Makumire, T. Zininga, J. Vahokoski, I. Kursula

This study characterizes the structure and thermal stability of PfHop, a Plasmodium falciparum protein involved in Hsp70-Hsp90 complex formation, revealing it as a monomeric protein with folded segments and flexible linkers.

bioRxiv · Dec 5, 2019Biochemistry

Atomic view into Plasmodium actin polymerization, ATP hydrolysis, and phosphate release

E.-P. Kumpula, A. J. Lopez, L. Tajedin, H. Han, I. Kursula

The paper investigates the structural mechanisms of Plasmodium actin polymerization, ATP hydrolysis, and phosphate release using crystallography, revealing how the A-loop regulates filament stability.

bioRxiv · Nov 9, 2018Biochemistry