Induction of exaggerated cytokine production in human peripheral blood mononuclear cells by a recombinant SARS-CoV-2 spike glycoprotein S1 and its inhibition by dexamethasone
O. A. Olajide, V. U. Iwuanyanwu, I. Lepiarz-Raba, A. A. Al-Hindawi
This study shows that SARS-CoV-2 spike glycoprotein S1 induces cytokine production in PBMCs, which is inhibited by dexamethasone, suggesting its anti-inflammatory role in reducing cytokine storm.
bioRxiv · Feb 3, 2021Pharmacology & Toxicology