Functional modulation of PTH1R activation and signalling by RAMP2
K. Nemec, H. Schihada, G. Kleinau, U. Zabel, E. O. Grushevskyi, P. Scheerer, M. J. Lohse, I. Maiellaro
This study shows RAMP2 modulates PTH1R activation and signalling, enhancing Gi3 sensitivity and β-arrestin2 recruitment in a ligand-dependent manner.
bioRxiv · Dec 8, 2021 · PreprintPharmacology & Toxicology