Author

H. Schihada

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Pharmacology & Toxicology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 4 Assay:proteomics· 4 Approach:experimental assay· 3 Approach:biophysical modeling· 2 Organism:human· 2

Frequent Co-Authors

G. Schulte· 3 shared M. Kowalski-Jahn· 2 shared A. Bacchin· 1 shared A. Turku· 1 shared C.-F. Bowin· 1 shared E. Kostenis· 1 shared E. O. Grushevskyi· 1 shared F. Andres· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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3 shared papersCell Biology

G. Schulte

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Cyclic peptide inhibitors stabilize Gq/11 heterotrimers

J. Muehle, M. J. Rodrigues, J. Alenfelder, L. Juergenliemke, R. Guixa-Gonzalez, A. Bacchin, F. Andres, M. Hennig, H. Schihada, M. Cruesemann, G. Koenig, E. Kostenis, G. Schertler, X. Deupi

This study determines the crystal structures of FR and YM bound to G11, revealing they stabilize Gq/11 heterotrimers by reinforcing the G and Gβ interface.

bioRxiv · Oct 24, 2023 · PreprintBiochemistry

WNT stimulation induced conformational dynamics in the Frizzled-Dishevelled interaction

C.-F. Bowin, P. Kozielewicz, L. Graetz, M. Kowalski-Jahn, H. Schihada, G. Schulte

The paper analyzes the FZD5-DVL2 interaction to uncover WNT-induced conformational dynamics in a ternary complex.

bioRxiv · Jul 19, 2022 · PreprintPharmacology & Toxicology

Functional modulation of PTH1R activation and signalling by RAMP2

K. Nemec, H. Schihada, G. Kleinau, U. Zabel, E. O. Grushevskyi, P. Scheerer, M. J. Lohse, I. Maiellaro

This study shows RAMP2 modulates PTH1R activation and signalling, enhancing Gi3 sensitivity and β-arrestin2 recruitment in a ligand-dependent manner.

bioRxiv · Dec 8, 2021 · PreprintPharmacology & Toxicology

Frizzled BRET sensors based on bioorthogonal labeling of unnatural amino acids reveal WNT-induced dynamics of the cysteine-rich domain.

M. Kowalski-Jahn, H. Schihada, A. Turku, T. Huber, T. P. Sakmar, G. Schulte

The paper develops BRET-based biosensors to study WNT-induced conformational changes in FZD CRD and shows CRD dynamics are not required for WNT/β-catenin signaling.

bioRxiv · May 1, 2021Cell Biology

Quantitative assessment of constitutive G protein-coupled receptor activity with BRET-based G protein biosensors

H. Schihada, R. Shekhani, G. Schulte

The paper validates BRET-based G protein biosensors to quantify constitutive GPCR signaling in living cells.

bioRxiv · Feb 5, 2021Cell Biology