Author

I. P. Caruso

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 3 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:protein folding & dynamics· 3 Assay:proteomics· 3 Organism:virus· 2 Approach:biophysical modeling· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Organism:Drosophila· 1

Frequent Co-Authors

F. C. L. Almeida· 3 shared K. Sanches· 2 shared A. A. Vasconcelos· 1 shared A. Akkouche· 1 shared A. B. Carvalho· 1 shared A. Da Poian· 1 shared A. L. Marques· 1 shared A. Pinheiro· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiophysics

F. C. L. Almeida

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A comprehensive evolutionary scenario for the origin and neofunctionalization of the Drosophila speciation gene Odysseus (OdsH)

W. Vilas Boas Nunes, D. Siqueira de Oliveira, G. de Rezende Dias, A. B. Carvalho, I. P. Caruso, J. Matos Biselli, N. Gueguen, A. Akkouche, N. Burlet, C. Vieira, C. M. A. Carareto

This study reevaluates the origin and neofunctionalization of the Drosophila speciation gene OdsH, showing its origin occurred 62 million years ago and its rapid neofunctionalization in male reproductive tracts.

bioRxiv · May 31, 2023 · PreprintEvolutionary Biology

Structure insights, thermodynamic profiles, dsDNA melting activity, and liquid-liquid phase separation of the SARS-CoV-2 nucleocapsid N-terminal domain binding to DNA

I. P. Caruso, V. S. Almeida, M. J. Amaral, G. C. Andrade, G. R. Araujo, T. S. Araujo, J. M. Azevedo, G. M. Barbosa, L. Bartkevihi, P. R. Bezerra, K. M. d. S. Cabral, I. O. Lourenco, C. L. F. Malizia-Motta, A. L. Marques, N. C. Mebus-Antunes, , F. C. L. Almeida

This study examines the structural and thermodynamic properties of SARS-CoV-2 N-terminal domain binding to DNA, revealing specific interactions and phase separation behavior.

bioRxiv · Jul 21, 2021 · PreprintBiophysics

Biophysical and dynamic characterization of a fine-tuned binding of the human Respiratory Syncytial Virus M2-1 core domain to long RNAs

I. P. Caruso, G. C. Guimaraes, V. B. Machado, M. A. Fossey, D. Willbold, F. C. L. Almeida, F. P. Souza

This paper characterizes the biophysical and dynamic properties of the hRSV M2-1 core domain binding to long RNAs, revealing a fine-tuned interaction that promotes RNA unfolding.

Journal of Virology · Nov 9, 2020Peer-reviewedBiophysics

Dynamics of the N-terminal domain of SARS-CoV-2 nucleocapsid protein drives dsRNA melting in a counterintuitive tweezer-like mechanism

I. P. Caruso, K. Sanches, A. Da Poian, A. Pinheiro, F. C. L. Almeida

This paper uses molecular dynamics simulations to show that the N-terminal domain of SARS-CoV-2 N protein destabilizes dsRNA through a tweezer-like motion, revealing a 1:1 stoichiometry and potential mechanisms for RNA melting.

bioRxiv · Aug 24, 2020 · PreprintBiophysics