Structure insights, thermodynamic profiles, dsDNA melting activity, and liquid-liquid phase separation of the SARS-CoV-2 nucleocapsid N-terminal domain binding to DNA
I. P. Caruso, V. S. Almeida, M. J. Amaral, G. C. Andrade, G. R. Araujo, T. S. Araujo, J. M. Azevedo, G. M. Barbosa, L. Bartkevihi, P. R. Bezerra, K. M. d. S. Cabral, I. O. Lourenco, C. L. F. Malizia-Motta, A. L. Marques, N. C. Mebus-Antunes, , F. C. L. Almeida
This study examines the structural and thermodynamic properties of SARS-CoV-2 N-terminal domain binding to DNA, revealing specific interactions and phase separation behavior.
bioRxiv · Jul 21, 2021 · PreprintBiophysics