Author

F. C. L. Almeida

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 5 Assay:proteomics· 3 Approach:experimental assay· 2 Organism:virus· 2 Approach:biophysical modeling· 1 Research Focus:cell-cell communication· 1 Assay:DNA methylation· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

I. P. Caruso· 3 shared K. Sanches· 2 shared A. A. Vasconcelos· 1 shared A. Da Poian· 1 shared A. L. Marques· 1 shared A. Pinheiro· 1 shared A. S. Pinheiro· 1 shared A. T. Da Poian· 1 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersBiophysics

I. P. Caruso

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Author profile →

5 papers

Recent·Most cited

Detection of Selenium/Sulphur substitution in the heterologous expression of Thioredoxin isoform 1 (Trx1) from Saccharomyces cerevisiae.

H. A. d. A. Filho, F. C. L. Almeida

This paper demonstrates the successful substitution of cysteines and methionines with selenocysteines and selenomethionines in Trx1 through heterologous expression and validates the method using Maldi-TOF and NMR spectroscopy.

bioRxiv · Nov 5, 2021 · PreprintBiochemistry

Structure insights, thermodynamic profiles, dsDNA melting activity, and liquid-liquid phase separation of the SARS-CoV-2 nucleocapsid N-terminal domain binding to DNA

I. P. Caruso, V. S. Almeida, M. J. Amaral, G. C. Andrade, G. R. Araujo, T. S. Araujo, J. M. Azevedo, G. M. Barbosa, L. Bartkevihi, P. R. Bezerra, K. M. d. S. Cabral, I. O. Lourenco, C. L. F. Malizia-Motta, A. L. Marques, N. C. Mebus-Antunes, , F. C. L. Almeida

This study examines the structural and thermodynamic properties of SARS-CoV-2 N-terminal domain binding to DNA, revealing specific interactions and phase separation behavior.

bioRxiv · Jul 21, 2021 · PreprintBiophysics

A systematic structural comparison of all solved small proteins (4-6 kDa) reveals the weight of disulfide bonds in proteins' foldability

M. H. Moreira, F. C. L. Almeida, T. Domitrovic, F. L. Palhano

The paper compares the structural features of small proteins with and without disulfide bonds, finding that bonded proteins have more apolar residues exposed to solvent and are harder to predict with Robetta.

bioRxiv · Mar 30, 2021 · PreprintBiochemistry

Biophysical and dynamic characterization of a fine-tuned binding of the human Respiratory Syncytial Virus M2-1 core domain to long RNAs

I. P. Caruso, G. C. Guimaraes, V. B. Machado, M. A. Fossey, D. Willbold, F. C. L. Almeida, F. P. Souza

This paper characterizes the biophysical and dynamic properties of the hRSV M2-1 core domain binding to long RNAs, revealing a fine-tuned interaction that promotes RNA unfolding.

Journal of Virology · Nov 9, 2020Peer-reviewedBiophysics

Dynamics of the N-terminal domain of SARS-CoV-2 nucleocapsid protein drives dsRNA melting in a counterintuitive tweezer-like mechanism

I. P. Caruso, K. Sanches, A. Da Poian, A. Pinheiro, F. C. L. Almeida

This paper uses molecular dynamics simulations to show that the N-terminal domain of SARS-CoV-2 N protein destabilizes dsRNA through a tweezer-like motion, revealing a 1:1 stoichiometry and potential mechanisms for RNA melting.

bioRxiv · Aug 24, 2020 · PreprintBiophysics