Author

I. Paassen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Benjak· 1 shared A. King-Yung Leung· 1 shared A. Naveed· 1 shared B. Daniel· 1 shared C. K. Ng· 1 shared D. A. Quigley· 1 shared D. Ayyildiz· 1 shared E. de Wit· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

A. Benjak

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

A double-negative prostate cancer subtype is vulnerable to SWI/SNF-targeting degrader molecules

P. D. Thienger, I. Paassen, X. Yao, P. D. Rubin, M. Lehner, N. Lillis, A. Benjak, S. Shah, A. King-Yung Leung, S. de Brot, A. Naveed, B. Daniel, M. Shi, J. Tremblay, J. Triscott, , M. A. Rubin

This study identifies a SWI/SNF-targeting therapy effective against a double-negative prostate cancer subtype, showing it reduces viability in both AR-dependent and WNT-dependent models.

bioRxiv · Mar 24, 2024Cancer Biology

SMARCB1 loss creates patient-specific MYC topologies that drive malignant rhabdoid tumor growth

N. Q. Liu, I. Paassen, L. Custers, H. Teunissen, D. Ayyildiz, J. He, E. W. Hoving, E. de Wit, J. Drost

This study shows that SMARCB1 loss leads to patient-specific MYC enhancer looping, driving MRT growth through epigenetic reprogramming.

bioRxiv · Nov 21, 2022 · PreprintCancer Biology