J. Drost

Functional avidity of anti-B7H3 CAR-T constructs predicts antigen density thresholds for triggering effector function

The paper evaluates how the functional avidity of anti-B7H3 CAR-T constructs relates to their ability to trigger effector function against tumors with varying antigen density.

Complex structural variation is prevalent and highly pathogenic in pediatric solid tumors

The paper identifies prevalent and pathogenic complex structural variations in pediatric solid tumors, linking them to adverse clinical outcomes and potential therapeutic targets.

An engineered tumor organoid model reveals cellular identity and signaling trajectories underlying translocation RCC.

This study creates an engineered tumor organoid model of tRCC using SFPQ-TFE3 fusion expression, revealing epithelium-to-mesenchymal differentiation and Wnt signaling involvement in tumor transformation.

Knocking out CD70 rescues CD70-specific nanoCAR T cells from antigen induced exhaustion

The paper shows that knocking out CD70 in CD70-specific nanoCAR T cells improves their functionality in vivo by preventing antigen-induced exhaustion.

SMARCB1 loss creates patient-specific MYC topologies that drive malignant rhabdoid tumor growth

This study shows that SMARCB1 loss leads to patient-specific MYC enhancer looping, driving MRT growth through epigenetic reprogramming.

Molecular characterization reveals subclasses of 1q gain in intermediate-risk Wilms tumors

The paper identifies subclasses of 1q gain in Wilms tumors by integrating genomic and expression data, revealing differences in mutational mechanisms and functional effects.

Single-cell transcriptomics reveals immune suppression and cell states predictive of patient outcomes in rhabdomyosarcoma.

This study uses single-cell transcriptomics to identify immune suppression and cell states in rhabdomyosarcoma that predict patient outcomes.

Oncogenic signalling is coupled to colorectal cancer cell differentiation state

This study shows oncogenic signalling in colorectal cancer is linked to cell differentiation states through a defined axis, with mutations affecting stemness and differentiation.

Mesenchymal tumor organoid models recapitulate rhabdomyosarcoma subtypes

This study generates tumor organoid models of rhabdomyosarcoma subtypes that closely resemble original tumors and can be used for drug screening and genetic modification.

Rewiring glucose metabolism improves 5-FU efficacy in glycolytic p53-deficient colorectal tumors

This study shows that rewiring glucose metabolism enhances 5-FU efficacy in p53-deficient colorectal tumors by altering nucleotide pools without increasing toxicity in healthy cells.

Modelling cancer immunomodulation using epithelial organoid cultures

This study uses CRC organoids to model immune-cancer interactions and assess immunomodulation by co-culturing with cytotoxic T cells.