The Amyloid Precursor Protein is a conserved Wnt receptor
T. Liu, M. Nicolas, T. Zhang, H. Rice, A. Soldano, A. Claeys, I. Petrova, L. Fradkin, B. De Strooper, B. A. Hassan
This study identifies Wnt ligands as binding partners of APP, showing that Wnt3a stabilizes APP while Wnt5a targets it for degradation, with functional consequences for neuronal development.
bioRxiv · Jan 18, 2021Cell Biology