T. Zhang

Chronic electroconvulsive shock disrupts hippocampal physiology and impairs associative memory in mice

This study shows that chronic electroconvulsive shock in mice impairs hippocampal synaptic function and associative memory, but not object or location memory.

AAV-Mediated Dual-Gene Therapy Restores Metabolic Function in Mice with Propionic Acidemi

This study demonstrates that dual-gene AAV therapy restores metabolic function and shows long-term safety in a mouse model of propionic acidemia.

An organoid co-culture model for probing systemic anti-tumor immunity in lung cancer

The paper develops a co-culture model of lung cancer organoids and peripheral blood mononuclear cells to study systemic anti-tumor immunity and predict immunotherapy outcomes.

Discovery of Potent Degraders of the Dengue Virus Envelope Protein

This study develops small molecule degraders of the dengue virus envelope protein, demonstrating their ability to induce proteosome-mediated degradation and providing a foundation for antiviral drug development.

Structural characterization of two full length γδTCR/CD3 complexes

This study reports cryoEM structures of two full-length γδ TCR/CD3 complexes, revealing similarities to β TCRs but with highly mobile extracellular domains and a dimeric assembly in one complex.

Equip Fusobacterium nucleatum genetic tool kits with compatible shuttle vectors and engineered intermediatory E. coli strains for enhanced transformation efficiency

This paper develops genetic tools for Fusobacterium nucleatum by engineering E. coli intermediates and shuttle vectors, achieving 5000 transformants per microgram plasmid.

Vimentin promotes collective cell migration through collagen networks via increased matrix remodeling and spheroid fluidity

Freeform robotic optical coherence tomography beyond the optical field-of-view limit

This paper introduces a freeform robotic OCT system to overcome the FOV limitation in imaging non-planar anatomies, demonstrating its application in imaging the mouse eye's aqueous humor outflow pathway.

Unraveling the impact of host genetics and factors on the urinary microbiome in a young population

This study characterizes the urinary microbiome in 1579 Chinese individuals, identifying host factors and genetic associations that influence microbial composition and urotype classification.

A versatile bacterial innate immunity protein directly senses two disparate phage proteins

This study shows that the bacterial immunity protein CapRelSJ46 can sense two distinct phage proteins using the same domain, highlighting its versatility in anti-phage defense.

Targeting oncogenic K-Ras mutants with a small-molecule degrader through Nedd4-1

This study develops a small-molecule degrader, XMU-MP-9, that promotes ubiquitination and degradation of K-Ras mutants, including K-RasG12V, by enhancing Nedd4-1 interaction with K-Ras.

Tumor-expressed SPPL3 supports innate anti-tumor immune responses.

This study shows that SPPL3 in tumor cells affects innate immune responses by modulating nsGSLs, reducing susceptibility to neutrophils, NK cells, and γδ T cells.

Insight into the Impact of Air Flow Rate on Algal-Bacterial Granules: Reactor Performance, Hydrodynamics by Computational Fluid Dynamics (CFD) and Microbial Community Analysis

This study examines how air flow rate affects nitrogen removal, granule formation, and microbial communities in algal-bacterial systems using CFD and microbial analysis.

MtrAB two-component system is crucial for the intrinsic resistance and virulence of Mycobacterium abscessus

This study shows that disrupting MtrA or MtrB in Mycobacterium abscessus increases antibiotic susceptibility and reduces virulence by affecting cell division and permeability.

Biologically informed machine learning modeling of immune cells to reveal physiological and pathological aging process

The paper constructs a transcriptomic atlas of immune cells across human lifespan and develops a biological age prediction model using scRNA-seq and bulk RNA-seq data.

Enhanced extracellular matrix remodeling due to embedded spheroid fluidization

This study uses a computational model to show that fluid-like tumor spheroids cause more ECM remodeling than solid-like spheroids due to shape fluctuations and cellular motility.

The origin and evolution of cultivated rice and genomic signatures of heterosis for yield traits in super-hybrid rice

This study investigates the evolutionary history of cultivated rice and identifies genomic signatures of heterosis in super-hybrid rice varieties.

Novel Ser74 of NF-kappaB/CgIkappaBalpha Phosphorylated by MAPK/ERK Regulates Temperature Adaptation in Oysters

The paper identifies a novel phosphorylation site (Ser74) in oyster NF-kappaB/CgI{kappa}B regulated by MAPK/ERK that mediates thermal adaptation through ubiquitin-proteasome degradation and nuclear translocation of CgREL.

High-throughput Screening of Compounds against Autoluminescent Nonreplicating Mycobacterium tuberculosis under Diverse Conditions

This paper develops an autoluminescent model to assess anti-tuberculosis drugs against nonreplicating M. tuberculosis, showing real-time light output correlates with colony-forming units and reveals drug efficacy differences under anaerobic vs aerobic conditions.

Alanine and glutamate catabolism ensure proper sporulation by preventing premature germination and providing energy respectively

The paper identifies roles for alanine and glutamate catabolism in bacterial sporulation, showing they prevent premature germination and provide energy, respectively.

Resting natural killer cells promote the progress of colon cancer liver metastasis by elevating tumor-derived sSCF

The paper identifies resting NK cells that promote colon cancer liver metastasis by enhancing tumor-derived sSCF through cell-to-cell interactions.

Establishment of an Inhalation Administration Noninvasive Murine Model for Rapidly Testing Drug Activity against Mycobacterium tuberculosis

This paper develops a non-invasive murine inhalation model using autoluminescent M. tuberculosis to rapidly assess drug efficacy against tuberculosis.

EmbB and EmbC Regulate the Sensitivity of Mycobacterium abscessus to Echinomycin

This study identifies EmbB and EmbC as regulators of Mycobacterium abscessus sensitivity to echinomycin, showing that EmbB mutations can partially compensate for EmbC loss and alter cell wall permeability.

Mutations in ClpC1 or ClpX subunit of the caseinolytic protease confer resistance to natural product ilamycins in mycobacteria

This study identifies two ilamycin analogs targeting mycobacterial Clp protease components and discovers mutations conferring resistance to these compounds.

Ubiquitin-mediated stabilization of SlPsbS regulates low night temperature tolerance in tomatoes

This study identifies a ubiquitin-mediated degradation pathway involving SlCV and SlCSN5A that regulates SlPsbS stability under low night temperatures in tomatoes.

The first discovery of SFTSV in the Centre of Metropolitan Beijing, China

This study identifies SFTSV circulation in central Beijing by surveying ticks and hedgehogs, revealing high seroprevalence and RNA prevalence in urban areas.

Hosts Manipulate Lifestyle Switch and Pathogenicity Heterogeneity of Opportunistic Pathogens in the Single-cell Resolution

The paper shows how Drosophila larvae influence the lifestyle and pathogenicity of Serratia marcescens at the single-cell level through transcriptomic and metabolic changes.

Reducing stomatal density by expression of a synthetic EPF increases leaf intrinsic water use efficiency and reduces plant water use in a C4 crop

This study shows that reducing stomatal density in sorghum via synthetic EPF expression improves water use efficiency without compromising carbon fixation, but with trade-offs in reproductive development.

A CRISPR-Nonhomologous End-Joining-based strategy for rapid and efficient gene disruption in Mycobacterium abscessus

This paper introduces a CRISPR-NHEJ strategy for efficient gene disruption in Mycobacterium abscessus and shows that homologous recombination and single-strand annealing components are required for NHEJ repair.

Early evolution of the ecdysozoan body plan

The paper describes a new Cambrian ecdysozoan species, Beretella spinosa, and suggests that ancestral ecdysozoans may have been non-vermiform.