Depletion of FH, an essential TCA cycle enzyme, drives proliferation in a two-step model
B. Solaimuthu, M. Lichtenstein, A. Hayashi, A. Khatib, I. Plaschkes, Y. Nevo, M. Tanna, S. Lavi, O. Pines, Y. D. Shaul
This study investigates how FH loss drives cell proliferation through adaptive mutations in oncogenic pathways despite initial DNA damage and growth inhibition.
bioRxiv · Jun 16, 2022 · PreprintCancer Biology