Author

A. Hayashi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 7 Bioengineering· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 9 Approach:experimental assay· 8 Research Focus:cancer & tumor microenvironment· 5 Approach:statistical model· 4 Research Focus:cell signaling & trafficking· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2

Frequent Co-Authors

C. A. Iacobuzio-Donahue· 4 shared L. Zhang· 4 shared A. Khatib· 3 shared A. P. Makohon-Moore· 3 shared B. Solaimuthu· 3 shared J. Hong· 3 shared M. Lichtenstein· 3 shared M. Tanna· 3 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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4 shared papersCancer Biology

C. A. Iacobuzio-Donahue

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Jet injection potentiates naked mRNA SARS-CoV-2 vaccine in mice and non-human primates by adding physical stress to the skin

S. Abbasi, M. Matsui-Masai, F. Yasui, A. Hayashi, T. Tockary, S. Akinaga, M. Kohara, K. Kataoka, S. Uchida

This study shows that jet injection improves naked mRNA vaccine efficacy in mice and non-human primates by enhancing delivery and immune response without systemic inflammation.

bioRxiv · Feb 27, 2023 · PreprintBioengineering

The metabolic enzyme EXT1 is sufficient to induce the epithelial-mesenchymal transition program in cancers

B. Solaimuthu, A. Khatib, A. Hayashi, M. Tanna, M. Lichtenstein, A. Karmi, Y. D. Shaul

This study shows that the metabolic enzyme EXT1 drives EMT in cancer by promoting HS biosynthesis, migration, and tumor formation.

bioRxiv · Jan 5, 2023 · PreprintCancer Biology

Depletion of FH, an essential TCA cycle enzyme, drives proliferation in a two-step model

B. Solaimuthu, M. Lichtenstein, A. Hayashi, A. Khatib, I. Plaschkes, Y. Nevo, M. Tanna, S. Lavi, O. Pines, Y. D. Shaul

This study investigates how FH loss drives cell proliferation through adaptive mutations in oncogenic pathways despite initial DNA damage and growth inhibition.

bioRxiv · Jun 16, 2022 · PreprintCancer Biology

Application of high-throughput, high-depth, targeted single-nucleus DNA sequencing in pancreatic cancer

H. Zhang, E.-R. Karnoub, S. Umeda, R. Chaligne, I. Masilionis, C. A. McIntyre, A. Hayashi, P. Sashittal, A. Zucker, K. Mullen, A. Makohon-Moore, C. A. Iacobuzio-Donahue

This study develops a scalable workflow for targeted single-nucleus DNA sequencing in pancreatic cancer, enabling high-resolution genomic analysis of tumor subclones and normal cells.

bioRxiv · Mar 6, 2022Cancer Biology

OXPHOS Promotes Apoptotic Resistance and Persistence in TH17 cells

H. Hong, N. Mbah, M. Shan, K. Loesel, L. Lin, P. Sajjakulnukit, A. Andren, A. Hayashi, B. Magnuson, Z. Li, Y. Xie, L. Zhang, Y. L. Lei, A. Opipari, R. J. Arguello, , C. A. Lyssiotis

This study shows that OXPHOS enhances TH17 cell survival and persistence by promoting mitochondrial fitness and anti-apoptotic markers.

bioRxiv · Oct 1, 2021 · PreprintImmunology

Dihydropyrimidinase-like 2 (DPYSL2) regulates breast cancer migration via a JAK/STAT3/vimentin axis

A. Abu Rmaileh, B. Solaimuthu, M. Ben Yosef, A. Khatib, M. Lichtenstein, M. Tanna, A. Hayashi, N. Pillar, Y. D. Shaul

This study identifies DPYSL2 as a regulator of breast cancer migration through the JAK/STAT3/vimentin axis, showing its role in cytoskeletal reorganization and metastasis.

bioRxiv · Mar 21, 2021Cancer Biology

Adaptive fitness in APC-mutant cells requires chromosome rearrangements

Y. Kawasaki, T. Hamaji, K. Owada, A. Hayashi, Y. Wu, T. Nogi, M. Okada, S. Sakai, N. Tokushige, S. Sasagawa, H. Nakagawa, Y. Kouyama, A. Niida, K. Mimori, T. Kuroda, , Y. Mimori-Kiyosue

The paper shows that APC-mutant cells gain adaptive fitness through chromosome rearrangements that restore AURKA activity and counteract mitotic defects.

bioRxiv · Sep 18, 2020 · PreprintCell Biology

Evolutionary Dynamics of Non-Coding Regions in Pancreatic Ductal Adenocarcinoma

A. Hayashi, Y.-j. Ho, A. P. Makohon-Moore, A. Zucker, J. Hong, J. G. Reiter, J. Huang, L. Zhang, M. A. Attiyeh, P. Baez, R. Kappagantula, J. P. Melchor, E. M. OReilly, N. D. Socci, S. Oki, , C. A. Iacobuzio-Donahue

This study investigates the evolutionary dynamics of non-coding regions in pancreatic cancer, finding higher mutational burden in noncoding DNA and similar mutational spectra between enhancers and coding DNA.

bioRxiv · Sep 11, 2020 · PreprintCancer Biology

Evolutionary Origins of Recurrent Pancreatic Cancer

H. Sakamoto, M. Attiyeh, J. Gerold, A. P. Makohon-Moore, A. Hayashi, J. Hong, R. Kappagantula, L. Zhang, J. Melchor, J. Reiter, A. Heyde, C. Bielski, A. Penson, D. Chakravarty, E. O'Reilly, , C. A. Iacobuzio-Donahue

This study identifies genetic features of recurrent pancreatic cancer through sequencing and finds that treatment-induced genetic changes and potential second primary tumors influence recurrence.

bioRxiv · Oct 31, 2019Cancer Biology

The Genetic Basis of Transcriptional and Spatial Heterogeneity of Basal-Like Features in Pancreatic Ductal Adenocarcinoma

A. Hayashi, J. Fan, R. Chen, Y.-j. Ho, A. P. Makohon-Moore, Y. Zhong, J. Hong, H. Sakamoto, M. A. Attiyeh, Z. A. Kohutek, L. Zhang, J. Huang, A. Boumiza, R. Kappagantula, P. Baez, , C. A. Iacobuzio-Donahue

The paper identifies genetic and transcriptional features of basal-like subtypes in pancreatic ductal adenocarcinoma, linking them to squamous histology and chromatin modifier mutations.

bioRxiv · Apr 4, 2019 · PreprintCancer Biology