Author

Y. D. Shaul

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Khatib· 4 shared M. Lichtenstein· 4 shared A. Hayashi· 3 shared B. Solaimuthu· 3 shared M. Tanna· 3 shared A. Abu Rmaileh· 2 shared A. Karmi· 1 shared G. Oren· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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4 shared papersCancer Biology

A. Khatib

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Author profile →

4 papers

Recent·Most cited

The metabolic enzyme EXT1 is sufficient to induce the epithelial-mesenchymal transition program in cancers

B. Solaimuthu, A. Khatib, A. Hayashi, M. Tanna, M. Lichtenstein, A. Karmi, Y. D. Shaul

This study shows that the metabolic enzyme EXT1 drives EMT in cancer by promoting HS biosynthesis, migration, and tumor formation.

bioRxiv · Jan 5, 2023 · PreprintCancer Biology

Depletion of FH, an essential TCA cycle enzyme, drives proliferation in a two-step model

B. Solaimuthu, M. Lichtenstein, A. Hayashi, A. Khatib, I. Plaschkes, Y. Nevo, M. Tanna, S. Lavi, O. Pines, Y. D. Shaul

This study investigates how FH loss drives cell proliferation through adaptive mutations in oncogenic pathways despite initial DNA damage and growth inhibition.

bioRxiv · Jun 16, 2022 · PreprintCancer Biology

Dihydropyrimidinase-like 2 (DPYSL2) regulates breast cancer migration via a JAK/STAT3/vimentin axis

A. Abu Rmaileh, B. Solaimuthu, M. Ben Yosef, A. Khatib, M. Lichtenstein, M. Tanna, A. Hayashi, N. Pillar, Y. D. Shaul

This study identifies DPYSL2 as a regulator of breast cancer migration through the JAK/STAT3/vimentin axis, showing its role in cytoskeletal reorganization and metastasis.

bioRxiv · Mar 21, 2021Cancer Biology

Glutathione Peroxidase 8 (GPX8)-IL6 axis is essential in maintaining breast cancer mesenchymal stem-like state and aggressive phenotype

A. Khatib, S. Balakrishnan, M. Ben-Yosef, G. Oren, A. Abu Rmaileh, M. Schlesinger, J. H. Axelrod, M. Lichtenstein, Y. D. Shaul

This study identifies the GPX8-IL6 axis as a key driver of the mesenchymal stem-like state and aggressive phenotype in breast cancer.

bioRxiv · Oct 25, 2019 · PreprintCancer Biology