Experimental and mathematical insights on the competition between poliovirus and a defective interfering genome
Y. Shirogane, E. Rousseau, J. Voznica, I. Rouzine, S. Bianco, R. Andino
The paper models the competition between poliovirus and defective interfering genomes, finding DI replicates faster but establishes an equilibrium with WT, reducing WT virion concentration by 5x.
bioRxiv · Jan 13, 2019 · PreprintMicrobiology