R. Andino

SARS-CoV-2 Nsp1 regulates translation start site fidelity to promote infection

This study identifies Nsp1's role in enhancing SARS-CoV-2 translation by interacting with EIF1A, leading to reduced viral titers when EIF1A is depleted.

A tradeoff between enterovirus A71 particle stability and cell entry

This study identifies a mutation in enterovirus A71 that increases particle stability but reduces cell entry efficiency, revealing structural changes in the capsid.

Targeting Nup358/RanBP2 by a viral protein disrupts stress granule formation

This paper identifies a viral protein that inhibits stress granule formation by targeting Nup358/RanBP2, revealing a mechanism by which viruses modulate cellular stress responses to promote infection.

Experimental and mathematical insights on the interactions between poliovirus and a defective interfering genome

The paper investigates how defective interfering genomes affect wild-type poliovirus replication using a mathematical model and experimental data, finding that DI replication and encapsidation are key factors in determining viral competition outcomes.

Ethacridine inhibits SARS-CoV-2 by inactivating viral particles in cellular models

This study identifies ethacridine, an FDA-approved antiseptic, as a potent inhibitor of SARS-CoV-2 by inactivating viral particles in cellular models.

Principles of dengue virus evolvability derived from genotype-fitness maps in human and mosquito cells

This study identifies principles of dengue virus evolvability by analyzing genotype-fitness maps in human and mosquito cells, revealing host-specific adaptation mechanisms and genetic load effects.

Genetic interactions shaping evolutionary trajectories in an RNA virus population

The paper analyzes mutation dynamics in a poliovirus population using high-resolution sequencing to identify interactions like clonal interference and hitchhiking that shape evolutionary trajectories.

Experimental and mathematical insights on the competition between poliovirus and a defective interfering genome

The paper models the competition between poliovirus and defective interfering genomes, finding DI replicates faster but establishes an equilibrium with WT, reducing WT virion concentration by 5x.

Hsp90 dictates viral sequence space by balancing the evolutionary tradeoffs between protein stability, aggregation and translation rate

The paper shows that reducing Hsp90 activity increases viral sequence diversity by altering the balance between protein stability, aggregation, and translation rate.