S. Bianco

Multiscale modelling of chromatin 4D organization in SARS-CoV-2 infected cells

This study uses polymer physics to model how SARS-CoV-2 infection alters chromatin organization and gene regulation in 4D.

A tradeoff between enterovirus A71 particle stability and cell entry

This study identifies a mutation in enterovirus A71 that increases particle stability but reduces cell entry efficiency, revealing structural changes in the capsid.

Aberrant paracrine signalling for bone remodelling underlies the mutant histone-driven giant cell tumour of bone.

This study identifies aberrant paracrine signaling between osteoprogenitors and osteoclasts driven by H3.3 mutations as a mechanism underlying giant cell tumor of bone and its response to treatment.

AI-driven prediction of SARS-CoV-2 variant binding trends from atomistic simulations

The paper presents an AI method to predict SARS-CoV-2 variant binding affinity trends using atomistic simulations with high accuracy and reduced simulation time.

Experimental and mathematical insights on the interactions between poliovirus and a defective interfering genome

The paper investigates how defective interfering genomes affect wild-type poliovirus replication using a mathematical model and experimental data, finding that DI replication and encapsidation are key factors in determining viral competition outcomes.

Comparison of the Hi-C, GAM and SPRITE methods by use of polymer models of chromatin

The paper compares Hi-C, GAM, and SPRITE methods using polymer models of chromatin to assess their accuracy and performance in capturing 3D genomic structures.

Genetic interactions shaping evolutionary trajectories in an RNA virus population

The paper analyzes mutation dynamics in a poliovirus population using high-resolution sequencing to identify interactions like clonal interference and hitchhiking that shape evolutionary trajectories.

Establishing the baseline for using plankton as biosensor

This paper establishes baseline morphological features for plankton species using image data to detect environmental perturbations, supporting their use as biosensors.

Stereo In-Line Holographic Digital Microscope

This paper introduces a stereo in-line holographic digital microscope that enables 3D imaging and classification of plankton using a single laser and white LED, reducing computational load and providing interactive 3D visualization.

Experimental and mathematical insights on the competition between poliovirus and a defective interfering genome

The paper models the competition between poliovirus and defective interfering genomes, finding DI replicates faster but establishes an equilibrium with WT, reducing WT virion concentration by 5x.

Complementary chromosome folding by transcription factors and cohesin

This study combines transcription factor and loop extrusion models to show cohesin acts as a molecular slip-link, not an active motor, in chromosome folding.