The TCR/peptide/MHC complex with a superagonist peptide shows similar interface and reduced flexibility compared to the complex with a self-peptide
I. Salutari, R. Martin, A. Caflisch
The paper compares the structural stability of TCR/pMHC complexes with a superagonist peptide and a self-peptide, finding similar interfaces but reduced flexibility in the superagonist complex.
bioRxiv · Mar 26, 2019Immunology