Author

A. Caflisch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Biophysics· 2 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Approach:experimental assay· 4 Research Focus:protein folding & dynamics· 4 Approach:statistical model· 4 Research Focus:drug response / drug discovery· 3 Approach:mechanistic / dynamical model· 3 Assay:structural biology· 3 Approach:deep learning· 2

Frequent Co-Authors

D. Huang· 3 shared L. Wiedmer· 3 shared R. K. Bedi· 3 shared E. V. Moroz-Omori· 2 shared I. M. Ilie· 2 shared Y. Li· 2 shared A. Dolbois· 1 shared A. Hunziker· 1 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersBiochemistry

D. Huang

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

The catalytic mechanism of the RNA methyltransferase METTL3

I. Corbeski, P. A. Vargas-Rosales, R. K. Bedi, J. Deng, D. Coelho, E. Braud, L. Iannazzo, Y. Li, D. Huang, M. Etheve-Quelquejeu, Q. Cui, A. Caflisch

This study reveals the catalytic mechanism of METTL3-14 by identifying two adenosine binding conformations, the methyl transfer transition state, and the roles of key residues in catalysis.

bioRxiv · Sep 6, 2023 · PreprintBiochemistry

The role of the first transmembrane helix in bacterial YidC: Insights from the crystal structure and molecular dynamics simulations

K. J. Nass, I. M. Ilie, M. J. Saller, A. J. M. Driessen, A. Caflisch, R. A. Kammerer, X. Li

This study reports the crystal structure of TmYidC and uses MD simulations to show how the TM1 helix enables YidC to switch between insertase and chaperone conformations.

bioRxiv · Jul 15, 2021Biophysics

Thermostable designed ankyrin repeat proteins (DARPins) as building blocks for innovative drugs

J. Schilling, C. Jost, I. M. Ilie, J. Schnabl, O. Buechi, R. S. Eapen, R. Truffer, A. Caflisch, P. Forrer

This paper identifies a mutation that significantly increases thermostability in DARPins, showing its broad applicability and relevance to a clinical drug.

bioRxiv · Apr 27, 2021Biochemistry

Combined computational and cellular screening identifies synergistic inhibition of SARS-CoV-2 by lenvatinib and remdesivir

M. O. Pohl, I. Busnadiego, F. Marrafino, L. Wiedmer, A. Hunziker, S. Fernbach, I. Glas, E. V. Moroz-Omori, B. G. Hale, A. Caflisch, S. Stertz

This study combines computational screening and cellular assays to identify lenvatinib and remdesivir as synergistic inhibitors of SARS-CoV-2 replication in Vero-CCL81 cells.

bioRxiv · Mar 19, 2021Microbiology

METTL3 inhibitors for epitranscriptomic modulation of cellular processes

E. V. Moroz-Omori, D. Huang, R. K. Bedi, S. J. Cheriyamkunnel, E. Bochenkova, A. Dolbois, M. D. Rzeczkowski, L. Wiedmer, A. Caflisch

This study identifies a METTL3 inhibitor, UZH1a, which reduces m6A methylation and inhibits leukemia cell growth, while its enantiomer UZH1b is inactive.

bioRxiv · Sep 25, 2020Biochemistry

Flexible binding of m6A reader protein YTHDC1 to its preferred RNA motif

Y. Li, R. K. Bedi, L. Wiedmer, D. Huang, P. Sledz, A. Caflisch

This study investigates how YTHDC1 binds to m6A-containing RNA motifs using simulations and experiments, revealing flexible 5 terminus interactions and conformational shifts.

bioRxiv · Sep 30, 2019Biophysics

The TCR/peptide/MHC complex with a superagonist peptide shows similar interface and reduced flexibility compared to the complex with a self-peptide

I. Salutari, R. Martin, A. Caflisch

The paper compares the structural stability of TCR/pMHC complexes with a superagonist peptide and a self-peptide, finding similar interfaces but reduced flexibility in the superagonist complex.

bioRxiv · Mar 26, 2019Immunology

Discovery of BAZ2A Bromodomain Ligands

D. Spiliotopoulos, E.-C. Wamhoff, G. Lolli, C. Rademacher, A. Caflisch

The paper identifies BAZ2A bromodomain ligands through high-throughput screening and validates their binding using NMR and crystal structures.

bioRxiv · Jun 7, 2017Biochemistry