R. Martin

The activated plant NRC4 immune receptor forms a hexameric resistosome

The study determines the cryo-EM structure of the auto-active NRC4 resistosome, revealing a hexameric configuration that triggers immune responses via cytosolic Ca2+ influx.

Pleiotropy alleviates the fitness costs associated with resource allocation trade-offs in immune signaling networks

This study uses an agent-based model to show that pleiotropy in immune signaling networks can be advantageous by reducing fitness costs from resource allocation trade-offs, especially in competitive host interactions.

Structural and functional analysis of the cerato-platanin-like effector protein Cpl1 suggests diverging functions in smut fungi

The paper presents the atomic structures of Cpl1 and Uvi2 from smut fungi, revealing their chitin-binding properties and suggesting diverging functions through structural differences.

High-throughput engineering of cytoplasmic- and nuclear-replicating large dsDNA viruses by CRISPR/Cas9

This paper optimizes CRISPR/Cas9 for high-throughput generation of marker-free recombinant large dsDNA viruses, improving efficiency and accuracy across cytoplasmic- and nuclear-replicating viruses.

The sphingolipid inhibitor myriocin increases susceptibility of Candida auris to amphotericin B

This study shows that myriocin, a sphingolipid inhibitor, increases susceptibility of Candida auris to amphotericin B and anidulafungin, suggesting sphingolipids as a target for overcoming resistance.

The network of SARS-CoV-2-cancer molecular interactions and pathways

This study identifies molecular interactions between SARS-CoV-2 and cancer pathways using integrated data, revealing potential impacts on oncogenes and key cellular processes.

Remdesivir and GS-441524 retain antiviral activity against Delta, Omicron, and other emergent SARS-CoV-2 variants

This study assesses the antiviral activity of remdesivir and GS-441524 against multiple SARS-CoV-2 variants, finding they remain effective against Delta, Omicron, and other variants.

Intra and inter-annual climatic conditions have stronger effect than grazing intensity on root growth of permanent grasslands

This study finds that climatic conditions have a stronger effect on root growth in grasslands than grazing intensity over two years.

Herpes simpex virus 2 (HSV-2) evolves faster in cell culture than HSV-1 by generating greater genetic diversity

This study shows HSV-2 generates more genetic diversity than HSV-1 in cell culture, leading to higher coding diversity and nonconservative mutations.

The narrow-spectrum anthelmintic oxantel is a potent agonist of a novel acetylcholine receptor subtype in whipworms

This study identifies a novel oxantel-sensitive acetylcholine receptor subtype in whipworms, explaining its high efficacy against Trichuris infections.

Structure of the activated Roq1 resistosome directly recognizing the pathogen effector XopQ

The paper presents the cryo-EM structure of the activated Roq1 NLR bound to XopQ, revealing direct effector recognition and resistosome activation mechanism.

Molecular basis for recognition of Listeria cell wall teichoic acid by the pseudo-symmetric SH3b-like repeats of a bacteriophage endolysin

The paper describes the atomic-level interaction between a bacteriophage endolysin's CBD500 domain and Listeria cell wall teichoic acid, identifying key epitopes and binding mechanisms.

Motor Protein MYO1C is Critical for Photoreceptor Opsin Trafficking and Visual Function

This study shows that MYO1C is essential for opsin trafficking to photoreceptor outer segments and normal visual function in mice.

A report on the detection and management of a finding of PSTVd (Potato Spindle Tuber Viroid) in potato breeding material in Northern Ireland, UK.

This paper reports the detection of PSTVd in potato breeding material in Northern Ireland and describes eradication efforts and risk assessment.

The TCR/peptide/MHC complex with a superagonist peptide shows similar interface and reduced flexibility compared to the complex with a self-peptide

The paper compares the structural stability of TCR/pMHC complexes with a superagonist peptide and a self-peptide, finding similar interfaces but reduced flexibility in the superagonist complex.

Structure and dynamics of the central lipid pool and protein components of the bacterial holo-translocon

The paper investigates the structure and dynamics of the bacterial holo-translocon using SANS and molecular dynamics simulations, revealing a central lipid core involved in membrane protein insertion.