I. Shirat

Splice-specific deficiency of the PTSD-associated gene PAC1 leads to a paradoxical age-dependent stress behavior

This study shows that splice-specific deficiency of PAC1 in zebrafish leads to age-dependent changes in stress behavior, with increased anxiety in larvae and resilience in adults.

SIRT6 is a DNA double-strand break sensor

This study identifies SIRT6 as a DNA double-strand break sensor that activates downstream repair pathways and prevents genomic instability.