Targeting the conserved active site of splicing machines with specific and selective small molecule modulators
I. Silvestri, J. Manigrasso, A. Andreani, N. Brindani, M. De Vivo, M. Marcia
This study demonstrates how small molecules interact with the conserved active site of splicing machines, showing their potential for designing splicing modulators targeting both bacterial introns and the human spliceosome.
bioRxiv · Jun 21, 2023Biochemistry