Interfacial water confers transcription factors with dinucleotide specificity
J. Taipale, E. Morgunova, Y. Yin, F. Zhu, T. Xiao, I. Sokolov, A. Popov, C. Laughton
The paper investigates how transcription factors recognize DNA dinucleotides through structural analysis, revealing water-mediated mechanisms that enhance specificity beyond mononucleotide recognition.
bioRxiv · Oct 3, 2023Biochemistry