F. Zhu

The pioneer transcription factor ELF2 remodels the nucleosome near transcription start sites

This study reveals how ELF2, a pioneer transcription factor, remodels nucleosomes near transcription start sites by unwrapping DNA and exposing chromatin, facilitating transcription initiation.

Epigenetic upregulation of carotid body angiotensin signaling increases blood pressure

This study shows perinatal nicotine exposure increases DNA methylation in the angiotensin II type 1 receptor gene in carotid bodies, enhancing angiotensin signaling and leading to hypertension.

Spatially Resolved Tumor Ecosystems and Cell States in Gastric Adenocarcinoma Progression and Evolution

This study integrates spatial transcriptomics and single-cell data from gastric cancer samples to reveal tumor ecosystem dynamics, evolutionary trajectories, and immune microenvironment features.

Sensory neurons regulate stimulus-dependent humoral immunity

This study shows sensory neurons regulate humoral immunity by releasing neuropeptides that influence B-cell responses and antibody production in bacterial infection and allergic asthma.

Interfacial water confers transcription factors with dinucleotide specificity

The paper investigates how transcription factors recognize DNA dinucleotides through structural analysis, revealing water-mediated mechanisms that enhance specificity beyond mononucleotide recognition.

Identification of S1PR4 as an immune modulator for favourable prognosis in HNSCC through unbiased machine learning

This study identifies S1PR4 as a key immune modulator linked to better prognosis in HNSCC through machine learning-based subtype classification and functional analysis.

Patient-derived organoids assist personalized treatment for a patient with multiple metastatic neuroendocrine carcinoma of the cervix

The paper uses patient-derived organoids to model metastatic neuroendocrine carcinoma of the cervix and guide personalized treatment based on drug screening.

Contribution of the delta-class glutathione S-transferase to agrochemical adaptation in Apis mellifera

This study characterizes AmGSTD1, a delta-class GST in honey bees, showing its role in agrochemical detoxification and antioxidative stress through structural and functional analysis.

Deciphering the role of the OmpC-Mla system in bile salt resistance

This study identifies a novel role for the OmpC-Mla system in bile salt resistance in E. coli, independent of its known function in maintaining outer membrane lipid asymmetry.

A pseudovirus-based method to dynamically mimic SARS-CoV-2-associated cell-to-cell fusion and transmission

This paper introduces a pseudovirus-based method to mimic SARS-CoV-2 cell-to-cell fusion and transmission, demonstrating its utility for screening inhibitors and studying variant fusogenic ability.

Spatiotemporal Genomic Profiling of Intestinal Metaplasia Reveals Clonal Dynamics of Gastric Cancer Progression

This study analyzes genomic and transcriptomic data from gastric samples to identify driver genes and clonal dynamics in intestinal metaplasia, showing their progression to gastric cancer and the role of microbial dysbiosis.

In vitro screening of non-antibiotic alternative growth promoter combinations in broilers

This study screens six non-antibiotic growth promoter combinations in vitro to improve feed efficiency and broiler health by evaluating digestibility, microbiota, and antioxidant capacity.

iTie controls intestinal tolerance through suppressing the NLRP6 inflammasome

This study identifies iTie as a regulator of intestinal tolerance by suppressing the NLRP6 inflammasome, with implications for treating bowel diseases.

Effects of nonantibiotic alternative growth promoter combinations on nutrient utilization, digestive enzyme activity, intestinal morphology, and cecal microflora of broilers

This study evaluates six nonantibiotic growth promoters in broilers, finding they improve nutrient utilization, intestinal morphology, and microbial composition compared to control and enramycin.

Computationally restoring the potency of a clinical antibody against SARS-CoV-2 Omicron subvariants

This paper computationally redesigns an antibody to restore potency against SARS-CoV-2 Omicron subvariants while maintaining efficacy against Delta and other variants.

An anti-steatosis response regulated by oleic acid through lipid droplet-mediated ERAD enhancement

This study shows oleic acid enhances ERAD via lipid droplets to increase SKN-1A levels, reducing steatosis and promoting longevity in C. elegans.

Systemic pesticides in a solitary bee pollen food store affect larval development and increase pupal mortality

This study shows that systemic pesticides and fungicides in pollen food stores delay larval development, reduce body weight, and increase pupal mortality in solitary bees.

Structure and function of one unclassified-class glutathione S-transferase in Leptinotarsa decemlineata

The paper functionally expresses and characterizes an unclassified-class GST from the Colorado potato beetle, showing its role in xenobiotic adaptation through enzyme activity and substrate interactions.

CXCR4 allows T cell acute lymphoblastic leukemia to escape from JAK1/2 and BCL2 inhibition through CNS infiltration

This study shows that combining JAK1/2 and BCL2 inhibitors in T-ALL leads to CNS infiltration, which is reduced by adding a CXCR4 inhibitor.

NOMA: a high-throughput microchip for robust, sequential measurements of secretions from the same single-cells

The paper introduces a microchip called NOMA that enables sequential tracking of secretions from the same single cells with high retention efficiency.

ATGs ubiquitination is required for circumsporozoite protein to subvert host innate immunity against malaria liver stage

The paper shows that CSP reduces ATG levels via ubiquitination by NEDD4, enabling EEFs to evade IFN-gamma-mediated killing in hepatocytes.

ERK signaling licenses SKN-1A/NRF1 for proteasome production and proteasomal stress resistance

This study identifies ERK1/2-mediated phosphorylation of NRF1 as critical for proteasome production and stress resistance, showing therapeutic potential in cancer.

Silencing NADPH-Cytochrome P450 reductase affects imidacloprid susceptibility, fecundity, and embryonic development in Leptinotarsa decemlineata

This study shows that silencing LdCPR in Colorado potato beetles increases imidacloprid susceptibility, reduces fecundity, and causes embryonic lethality.

PhenoImage: an open-source GUI for plant image analysis

PhenoImage is an open-source GUI tool for analyzing high-throughput plant phenotyping images, designed for users without programming skills.

Loss-of-function of Fbxo10, encoding a post-translational regulator of BCL2 in lymphomas, has no discernible effect on BCL2 or B lymphocyte accumulation in mice

This study shows that loss-of-function mutations in Fbxo10 do not increase BCL2 or B lymphocyte numbers in mice, suggesting redundant regulation of BCL2 by other ubiquitin ligases.

Association of gut microbiota with cerebral cortex and cerebrovascular abnormality in human mild traumatic brain injury

This study identifies gut microbiota changes and their associations with cerebral cortex and cerebrovascular abnormalities in human mild traumatic brain injury.

SeedExtractor: an open-source GUI for seed image analysis

SeedExtractor is an open-source GUI tool for rapid and accurate seed size and color measurement across plant species, validated on rice with genome-wide association analysis.

Wild emmer introgressions alter root-to-shoot growth dynamics in response to water stress

The paper examines how wild emmer introgressions affect root-to-shoot growth dynamics under water stress in wheat, identifying a line with high plasticity and candidate genes for stress adaptation.

Redox proteomics of stomatal immunity reveals role of a lipid transfer protein in plant defense

The study identifies redox-sensitive proteins in guard cells during stomatal immunity and characterizes a lipid transfer protein as a redox sensor in plant defense.

HTCC as a highly effective polymeric inhibitor of SARS-CoV-2 and MERS-CoV

This paper evaluates HTCC as a potential inhibitor for SARS-CoV-2 and MERS-CoV, highlighting its antiviral activity against highly pathogenic coronaviruses.