Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates
K. O. Saunders, N. Pardi, R. Parks, S. Santra, Z. Mu, L. L. Sutherland, R. Scearce, M. Barr, A. Eaton, G. Hernandez, D. Goodman, M. J. Hogan, I. Tombacz, D. Gordon, R. W. Rountree, , B. F. Haynes
This study compares the immunogenicity of mRNA-LNP vaccines to protein vaccines in nonhuman primates, finding comparable or superior HIV-1 antibody responses.
bioRxiv · Dec 30, 2020Immunology