Author

I. Topchu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

I. Bychkov· 3 shared P. Makhov· 3 shared Y. Boumber· 3 shared A. Deneka· 1 shared A. Kudinov· 1 shared C. Lengner· 1 shared D. Gursel· 1 shared E. A. Golemis· 1 shared

Activity by Year

2023-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersCancer Biology

I. Bychkov

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

NSD1 supports cell growth and regulates autophagy in HPV-negative head and neck squamous cell carcinoma.

I. Topchu, I. Bychkov, D. Gursel, P. Makhov, Y. Boumber

This study identifies NSD1 as a regulator of cell growth and autophagy in HPV-negative HNSCC, showing its role in Akt/mTORC1 signaling and autophagic flux.

bioRxiv · Sep 19, 2023Cancer Biology

Musashi-2 (MSI2) regulation of DNA damage response in lung cancer

I. Bychkov, A. Deneka, I. Topchu, R. P. Pangeni, C. Lengner, J. Karanicolas, E. A. Golemis, P. Makhov, Y. Boumber

This study shows MSI2 promotes lung tumorigenesis by enhancing ATM expression and DNA damage response, suggesting MSI2 as a potential therapeutic target in lung cancer.

bioRxiv · Jun 13, 2023 · PreprintCancer Biology

Regulation of VEGFR2 and AKT signaling by Musashi-2 in lung cancer

I. Bychkov, I. Topchu, P. Makhov, A. Kudinov, J. D. Patel, Y. Boumber

This study identifies MSI2 as a regulator of VEGFR2 and AKT signaling in NSCLC, showing MSI2 directly binds to VEGFR2 and PTEN mRNAs and correlates with VEGFR2 and VEGF-A levels.

bioRxiv · Mar 29, 2023 · PreprintCell Biology